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IBCSG 24-02 / BIG 2-02 (SOFT) 

A phase III trial evaluating the role of ovarian function suppression and the role of exemestane as adjuvant therapies for premenopausal women with endocrine responsive breast cancer

Suppression of Ovarian Function Trial (SOFT)


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Co-SOFT Substudy

The Cognitive Function Substudy is investigating cognitive function for patients participating in the SOFT trial in selected centers.

SOFT-EST Substudy

The SOFT-EST Substudy investigates estrogen levels at different timepoints during the first 4 years of protocol treatment among patients receiving triptorelin plus either tamoxifen (arm B) or exemestane (arm C).

Results & Publications


Study Chairs
BIG: Dr. Prue Francis - Melbourne, Australia
US Intergroup: Dr. Gini Fleming - Chicago, USA

Dr. Meredith Regan, Dr. Weixiu Luo, Dr. P. Kathryn Gray

Trial Coordinators
Holly Shaw

Data Managers
Karolyn Scott, Jocelyn Swick-Jemison, Monica Greco, Adriana Mora de Karausch, Amy Dickinson, Patricia Gonzalez

IBCSG Data Management Center/FSTRF
4033 Maple Road
Amherst, New York 14226 USA
Phone: +1 716 834 0900
Fax: +1 716 833 3990
Email: ibcsg24-26_STP@fstrf.org

Date of Activation
August 4, 2003

Date of Closure
January 31, 2011

Targeted Accrual
3000 patients

Final Accrual
3066 patients

Substudies Co-SOFT Substudy
Results Publications Results & Publications
Other Pathology


Benefiz-Gala mit Spitzenkoch Anton Mosimann Freitag 30. September 2016 im Park Hyatt

RACE FOR LIFE - mit Power gegen Krebs am 11. September 2016 auf dem Bundesplatz in Bern

PINK GOLF TOUR 2016 Golf  Kyburg 25.5.2016 / Golf Gams 30.5.2016 / Golf Winterberg 7.7.2016 

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