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IBCSG 24-02 / BIG 2-02 (SOFT) 

A phase III trial evaluating the role of ovarian function suppression and the role of exemestane as adjuvant therapies for premenopausal women with endocrine responsive breast cancer

Suppression of Ovarian Function Trial (SOFT)

DESIGN

please click on the picture to see a larger version

Co-SOFT Substudy


The Cognitive Function Substudy is investigating cognitive function for patients participating in the SOFT trial in selected centers.

SOFT-EST Substudy


The SOFT-EST Substudy investigates estrogen levels at different timepoints during the first 4 years of protocol treatment among patients receiving triptorelin plus either tamoxifen (arm B) or exemestane (arm C).

Results & Publications


Publications

Study Chairs
BIG: Dr. Prue Francis - Melbourne, Australia
US Intergroup: Dr. Gini Fleming - Chicago, USA

Statistician
Dr. Meredith Regan, Dr. Yang Feng
Trial Coordinators
Holly Shaw, Vanessa Palermo

Data Managers
Karolyn Scott, Jocelyn Swick-Jemison, Monica Greco, Adriana Mora de Karausch, Adrianna Cesario, Amy Dickinson, Vanessa Palermo, Patricia Gonzalez

IBCSG Data Management Center/FSTRF
4033 Maple Road
Amherst, New York 14226 USA
Phone: +1 716 834 0900
Fax: +1 716 836 6097
Email: ibcsg24-26_STP@fstrf.org

Date of Activation
August 4, 2003

Date of Closure
January 31, 2011

Targeted Accrual
3000 patients

Final Accrual
3066 patients


Substudies Co-SOFT Substudy
Results Publications Results & Publications
Other Pathology


News

01.10.2014:
Benefiz-Gala mit Anton Mosimann Mittwoch 1. Oktober 2014 18.30 Uhr AURA, Bleicherweg 5, 8001 Zürich

11.07.2014:
New publications are available  

01.06.2014:
New treatment option for young women with hormone‐sensitive breast cancer.

All News

 
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