DESIGN

Note: Participation in an adjuvant treatment trial does not, in general, exclude patients from POEMS.
If you would like to register patients from IBCSG 22-00 also into POEMS, those randomized into Arm A of IBCSG 22-00 would be eligible. Only patients randomized to the maintenance therapy arm would not be eligible for POEMS. Patients could, therefore, only participate in both studies if, following randomization to the standard arm, a one week delay before starting chemotherapy (which is required if randomized to the intervention arm on POEMS) is permissible.