IBCSG is a Swiss foundation governed by the IBCSG Foundation Council. The Scientific Committee oversees the research agenda, and the Biological Protocol Working Group focuses on research involving collected tissue. All clinical trials are reviewed by an internal Ethics Committee. Interim and final results and safety reports from all ongoing clinical trials are reviewed semi-annually by the Data and Safety Monitoring Committee (DSMC), an independent advisory group of expert oncologists, a statistician and a patient representative. IBCSG is headquartered in Bern, Switzerland, with Statistical Center at Dana-Farber Cancer Institute, Boston, USA, Data Management Center at Frontier Science Foundation, Amherst, USA, and Central Pathology Review Office at the European Institute of Oncology, Milan, Italy.