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A study evaluating the pregnancy outcomes and safety of interrupting endocrine therapy for young women with endocrine responsive breast cancer who desire pregnancy (POSITIVE).
Specific publication list for Trial 48-14 (September 2025)
Results from the POSITIVE study were presented at ESMO 2025
Secondary analysis results of the POSITIVE Study published in the Journal of Clinical Oncology
Results from the POSITIVE study were presented at the 2022 San Antonio Breast Cancer Symposium

The International Breast Cancer Study Group (IBCSG) with the collaboration and financial support of the young patient group of Southern Switzerland “Anna dai Capelli Corti” has developed a video to promote awareness about the IBCSG 48-14/BIG 8-13 POSITIVE study. The goal is to inform the scientific and patient communities about the availability of a controlled clinical study for young women with endocrine-responsive early breast cancer who wish a baby and to sensitize the health providers about the aspects unique to this population such as fertility and pregnancy.
The video sees the participation of two young breast cancer survivors, Dr. Olivia Pagani and Dr. Fedro Peccatori as breast cancer experts and POSITIVE study scientific co-chairs and Dr. Gabriella Bianchi, psycho-oncologist.
Trailer (4 min): https://youtu.be/rIPkvmQS_3g
Full version (14 min): http://bit.ly/2BeXk8w
ETOP IBCSG Partners Foundation
Effingerstrasse 33
3008 Bern, Switzerland
Contact
Phone: +41 31 511 94 00
E-mail: contact@etop.ibcsg.org